发明授权
US5492825A Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding
vectors, and transformed cells
失效
哺乳动物内向整流钾通道cDNA，IRK1，相应载体和转化细胞
- 专利标题： Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
- 专利标题（中）： 哺乳动物内向整流钾通道cDNA，IRK1，相应载体和转化细胞
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申请号： US103445申请日： 1993-08-06
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公开(公告)号： US5492825A公开(公告)日： 1996-02-20
- 发明人: Lily Y. Jan , Yuh N. Jan , Yoshihiro Kubo
- 申请人： Lily Y. Jan , Yuh N. Jan , Yoshihiro Kubo
- 申请人地址： CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： CA Oakland
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/705 ; C12N15/12 ; C12N1/21 ; C12N5/10 ; C12N15/63
摘要：
This disclosure relates to two separate and distinct inward rectifier K.sup.+ channel expression products and the the genes which encode each expression product. The IRK1 gene (SEQ. ID NO: 1) encodes an inward rectifier K.sup.+ channel and the GIRK1 gene (SEQ. ID NO: 31) encodes a G protein coupled muscarinic K.sup.+ channel. The disclosure relates to the uses of these expression products, particularly in combination with identifying physiological processes mediated by these channels, such as regulation of heartbeat and insulin release and materials modulating or blocking same.
公开/授权文献
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