A process for making a cellulosic fibrous structure such as paper. In one embodiment, the fibrous structure has high and low basis weight regions. The high basis weight region is subdivided into low density regions, so that a fibrous structure having three regions is produced. In a second embodiment, the fibrous structure has four regions. Both the high and low basis weight regions are further subdivided into high and low density regions. The process comprises applying noncoincident differential pressure to selected regions of an embryonic fibrous structure.