发明授权
- 专利标题: Dosage forms having zero-order dihydropyridine calcium antagonist release
- 专利标题(中): 剂型具有零级二氢吡啶钙拮抗剂释放
-
申请号: US14836申请日: 1993-02-08
-
公开(公告)号: US5439687A公开(公告)日: 1995-08-08
- 发明人: Sabine Compassi
- 申请人: Sabine Compassi
- 申请人地址: CHX Zofingen
- 专利权人: Siegfried Pharma AG
- 当前专利权人: Siegfried Pharma AG
- 当前专利权人地址: CHX Zofingen
- 优先权: CHX00464/92 19920217
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K9/22 ; A61K9/28 ; A61K31/44 ; A61K31/4422 ; A61K47/38 ; A61K9/36 ; A61K9/52
摘要:
Pharmaceutical dosage forms having a linear release rate of the 0.sup.th order for the once-daily oral administration of 20-120 mg of nifedipine or of another calcium antagonist of the dihydropyridine type, characterised by a homogeneous matrix containing 2-50% by weight of hydroxypropylmethylcellulose having an average molecular weight of 20,000-250,000, 5-60% by weight of a calcium antagonist of the dihydropyridine type, as well as customary excipients compatible with the formulation, such as lipophilic or hydrophilic liberation controllers, fillers, flow-regulating agents, lubricants and, optionally, film coatings.
公开/授权文献
- US4237564A Waterbed construction 公开/授权日:1980-12-09
信息查询