发明授权
- 专利标题: Muscarinic receptor antagonists
- 专利标题(中): 毒蕈碱受体拮抗剂
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申请号: US678941申请日: 1991-04-29
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公开(公告)号: US5422358A公开(公告)日: 1995-06-06
- 发明人: Peter E. Cross , Alexander R. Mackenzie
- 申请人: Peter E. Cross , Alexander R. Mackenzie
- 申请人地址: NY New York
- 专利权人: Pfizer Inc
- 当前专利权人: Pfizer Inc
- 当前专利权人地址: NY New York
- 优先权: GBX8825505 19881101
- 主分类号: A61K31/4427
- IPC分类号: A61K31/4427 ; A61K31/443 ; A61K31/4433 ; A61K31/445 ; A61K31/451 ; A61K31/495 ; A61P1/00 ; A61P25/02 ; C07D211/34 ; C07D401/06 ; C07D401/12 ; C07D405/06 ; C07D405/12 ; C07D409/06 ; C07D409/12
摘要:
Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein: Y is a direct link, --CH.sub.2 --, --(CH.sub.2).sub.2 --, --CH.sub.2 O-- or --CH.sub.2 S--; R is --CN or --CONH.sub.2 ; and R.sup.1 is ##STR2## where X and X.sup.1 are each independently O or CH.sub.2 ; and m is 1, 2 or 3, are muscarinic receptor antagonists useful in the treatment of diseases and conditions associated with the altered motility and/or tone of smooth muscle, such as irritable bowel syndrome.
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