发明授权
US5362477A 19F magnetic resonance imaging agents which include a nitroxide moiety
失效
19F磁共振成像剂，其包括氮氧化物部分
- 专利标题： 19F magnetic resonance imaging agents which include a nitroxide moiety
- 专利标题（中）： 19F磁共振成像剂，其包括氮氧化物部分
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申请号： US950343申请日： 1992-12-01
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公开(公告)号： US5362477A公开(公告)日： 1994-11-08
- 发明人: Dennis A. Moore , Max D. Adams , William P. Cacheris , David H. White , Muthunadar P. Periasamy , Raghavan Rajagopalan , Lynn A. deLearie , Steven R. Woulfe
- 申请人： Dennis A. Moore , Max D. Adams , William P. Cacheris , David H. White , Muthunadar P. Periasamy , Raghavan Rajagopalan , Lynn A. deLearie , Steven R. Woulfe
- 申请人地址： MO St. Louis
- 专利权人： Mallinckrodt Medical, Inc.
- 当前专利权人： Mallinckrodt Medical, Inc.
- 当前专利权人地址： MO St. Louis
- 主分类号： A61K49/06
- IPC分类号： A61K49/06 ; A61B5/055
摘要：
Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize .sup.19 F magnetic resonance contrast media having enhanced .sup.19 F relaxivity. Fluorine-containing compounds having enhanced .sup.19 F relaxation properties resulting from direct association with an unpaired spin are disclosed. The fluorine-containing compound is associated with the unpaired spin by covalent attachment of a stable free radical, by complexation of a fluorinated complexing agent with a paramagnetic metal ion, or by salt formation or charge neutralization of a paramagnetic ion.
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