Radio frequency power for melting, sealing and welding plastic tubing compressed between a pair of manually or automatically actuated electrically conducting jaws of a hand held or fixed base tubing sealer is regulated by a pulse width modulator controlling the duty cycle of applied constant voltage pulses. A predetermined change of impedance of the tubing during compression and melting is detected to regulate the power applied and to ensure a weld of predetermined physical parameters. On completion of the weld, a first timer is reset and a further weld may be made. In the event of impedance mismatch, a second timer inhibits further application of power and resetting of the first timer. The use of the pulse width modulator enhances conservation of power and accommodates portability of the tubing sealer through use of rechargeable batteries as the power source.