发明授权
- 专利标题： Azavesamicols
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申请号： US893129申请日： 1992-06-03
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公开(公告)号： US5338852A公开(公告)日： 1994-08-16
- 发明人: Simon M. N. Efange , Stanley M. Parsons
- 申请人： Simon M. N. Efange , Stanley M. Parsons
- 申请人地址： MN Minneapolis
- 专利权人： Regents of the University of Minnesota
- 当前专利权人： Regents of the University of Minnesota
- 当前专利权人地址： MN Minneapolis
- 主分类号： G01N33/566
- IPC分类号： G01N33/566 ; A61K31/445 ; A61K31/4545 ; A61K49/00 ; A61K49/06 ; A61K49/08 ; A61K51/00 ; A61K51/04 ; C07D211/56 ; C07D211/58 ; C09B57/00 ; C09K11/07 ; C07D211/40
摘要：
The compounds are vesamicol (hydroxylated phencyclidine (PCP) isomer trans-2-(4-phenyl-piperidino)cyclohexanol) derivatives with anticholinergic properties termed herein "azavesamicols" in which the cyclohexyl group of vesamicol is replaced with a heterocycle of similar size, the piperidyl ring. The compounds bind to the vesamicol receptor, a cytoplasmically-oriented site on the cholinergic synaptic vesicle, which is associated with the vesicular transporter of acetylcholine.
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