发明授权
US5296493A 1-substituted-2-(N-pheny
l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related
compounds and their use in treating calcium overload in brain cells
失效
1-取代-2-(N-苯基-N-(苯甲基)甲胺)-4,5-二氢咪唑及其相关化合物及其在脑细胞中治疗钙超载中的应用
- 专利标题: 1-substituted-2-(N-pheny l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells
- 专利标题(中): 1-取代-2-(N-苯基-N-(苯甲基)甲胺)-4,5-二氢咪唑及其相关化合物及其在脑细胞中治疗钙超载中的应用
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申请号: US704469申请日: 1991-05-23
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公开(公告)号: US5296493A公开(公告)日: 1994-03-22
- 发明人: Peter Moldt , Elsebet O. Nielsen
- 申请人: Peter Moldt , Elsebet O. Nielsen
- 申请人地址: DKX Glostrup
- 专利权人: NeuroSearch A/S
- 当前专利权人: NeuroSearch A/S
- 当前专利权人地址: DKX Glostrup
- 主分类号: C07D233/24
- IPC分类号: C07D233/24 ; C07D233/54 ; C07D233/60 ; C07D235/14 ; C07D401/12 ; C07D403/06 ; C07D405/12 ; A61K31/415 ; A61K31/44 ; C07D233/61 ; C07D401/06
摘要:
The present patent application discloses compounds of the formula ##STR1## wherein R.sup.1 is C.sub.1-10 saturated or unsaturated alkyl; or ##STR2## wherein R'" is H or ##STR3## R.sup.2 is phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; benzyl which may be substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; pyridyl; or cyclohexyl;R.sup.3 phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; naphthyl which may be substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; pyridyl; C.sub.1-6 unsaturated alkyl; furanyl;R.sup.4 is H, C.sub.1-6 -alkyl, or benzyl; or ##STR4## together form ##STR5## R' and R" are each hydrogen or together form an extra benzo ring; and wherein the dotted line represents an optional extra bond between the two carbon atoms designated .alpha. and .beta.,or a pharmaceutically-acceptable addition salt thereof.The compounds are useful as pharmaceuticals, for example in the treatment of Ca overload in brain cells.
公开/授权文献
- US5746991A Composition for growing laser crystals 公开/授权日:1998-05-05
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