Invention Grant
US5234931A Heteroaryl-8-azabicyclo[3.2.1]octanes as antipsychotic agents,
5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of
serotonin
失效
杂芳基-8-氮杂双环[3.2.1]辛烷作为抗精神病药，5-HT3受体拮抗剂和5-羟色胺再摄取抑制剂
- Patent Title: Heteroaryl-8-azabicyclo[3.2.1]octanes as antipsychotic agents, 5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of serotonin
- Patent Title (中): 杂芳基-8-氮杂双环[3.2.1]辛烷作为抗精神病药，5-HT3受体拮抗剂和5-羟色胺再摄取抑制剂
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Application No.: US831027Application Date: 1992-02-04
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Publication No.: US5234931APublication Date: 1993-08-10
- Inventor: Edward J. Glamkowski , David M. Fink , Barbara E. Kurys , Yulin Chiang
- Applicant: Edward J. Glamkowski , David M. Fink , Barbara E. Kurys , Yulin Chiang
- Applicant Address: NJ Somerville
- Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
- Current Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
- Current Assignee Address: NJ Somerville
- Main IPC: C07D451/02
- IPC: C07D451/02
Abstract:
This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifluoromethoxy, cyano, trifluoromethyl, ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifluoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic agents, as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.
Public/Granted literature
- US4727006A Method of monitoring electrochemical cells Public/Granted day:1988-02-23
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