发明授权
US5225404A Methods of treating colon tumors with tumor-inhibiting camptothecin
compounds
失效
用肿瘤抑制喜树碱化合物治疗结肠肿瘤的方法
- 专利标题: Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
- 专利标题(中): 用肿瘤抑制喜树碱化合物治疗结肠肿瘤的方法
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申请号: US432066申请日: 1989-11-06
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公开(公告)号: US5225404A公开(公告)日: 1993-07-06
- 发明人: Beppino C. Giovannella , Leroy F. Liu , Milan Potmesil , Monroe C. Wall , Robert F. Silber , Mansukh C. Wani
- 申请人: Beppino C. Giovannella , Leroy F. Liu , Milan Potmesil , Monroe C. Wall , Robert F. Silber , Mansukh C. Wani
- 申请人地址: NY New York
- 专利权人: New York University
- 当前专利权人: New York University
- 当前专利权人地址: NY New York
- 主分类号: A61K31/47
- IPC分类号: A61K31/47
摘要:
The present invention provides methods of treating malignant colon and colo-rectal cancer in mammals, by reducing or inhibiting or retarding such colon cancer tumors in mammals. These methods employ the administration of a tumor-inhibiting or reducing camptothecin compound, e.g., 9-amino-20(RS)-camptothecin, 10,11-methylenedioxy-20(RS)-camptothecin, and the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof. Also provided are pharmaceutical formulations.
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