Invention Grant
- Patent Title: Antibacterial cephalosporin compounds
- Patent Title (中): 抗生素CEPHOROSPORIN化合物
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Application No.: US189936Application Date: 1988-05-03
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Publication No.: US5189157APublication Date: 1993-02-23
- Inventor: Chung-Chen Wei , Kevin F. West
- Applicant: Chung-Chen Wei , Kevin F. West
- Applicant Address: NJ Nutley
- Assignee: Hoffmann La Roche Inc.
- Current Assignee: Hoffmann La Roche Inc.
- Current Assignee Address: NJ Nutley
- Main IPC: C07D501/22
- IPC: C07D501/22 ; A61K31/545 ; C07D501/18 ; C07D501/26 ; C07D501/34 ; C07D501/36 ; C07D501/38 ; C07D501/46 ; C07D501/57
Abstract:
There are presented antibacterial cephalosporins having broad antimicrobial activity as well as intermediates for their formation, such compounds having the formula ##STR1## wherein X is ##STR2## R is hydrogen or a carboxylic acid protecting group; R.sub.1 is hydrogen or an acyl group;R.sub.2 is hydrogen or lower alkoxy; andR.sub.3 is carbocyclic aryl or alkyl carbocyclic aryl substituted on the ring with two or more of hydroxy and/or lower alkanoyl ester groups, with halogen being an optional additional ring substituent;as well as the corresponding readily hydrolyzable esters, pharmaceutically acceptable salts and hydrates of these compounds where R is hydrogen.
Public/Granted literature
- US6021972A Sheet material winding core Public/Granted day:2000-02-08
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