发明授权
- 专利标题: Benzazecine derivatives for cognitive and memory functions
- 专利标题(中): 苯并嗪衍生物用于认知和记忆功能
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申请号: US395380申请日: 1989-08-17
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公开(公告)号: US4957911A公开(公告)日: 1990-09-18
- 发明人: Werner Aschwanden , Rene Imhof , Roland Jakob , Emilio Kyburz
- 申请人: Werner Aschwanden , Rene Imhof , Roland Jakob , Emilio Kyburz
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 优先权: CHX266/86 19860123
- 主分类号: A61K31/395
- IPC分类号: A61K31/395 ; A61P25/28 ; C07D221/10 ; C07D225/06
摘要:
Benzazecinediones of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen or chlorine, R.sup.3 is hydrogen, fluorine, chlorine, bromine or methoxy, R.sup.4 is hydrogen, chlorine or methoxy and R.sup.5 is hydrogen, acetyl, propionyl, benzoyl, chlorobenzoyl, methoxybenzoyl or phenylacetyl, with the proviso that 2 or 3 of the groups R.sup.1 to R.sup.4 are hydrogen, as well as many of the corresponding benzo[f]quinolines from which these benzazecinediones can be prepared by oxidation are suitable for the control or prevention of cerebral insufficiency or for the improvement of cognitive functions in mammals. They can be produced according to various processes and can be prepared into pharmaceutical compositions.
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