发明授权
US4681952A Intermediates in the preparation of
2,2-dimethyl-3-aryl-cyclopropanecarboxylic acids and esters
失效
中间体制备2,2-二甲基-3-芳基 - 环丙烷羧酸和酯
- 专利标题: Intermediates in the preparation of 2,2-dimethyl-3-aryl-cyclopropanecarboxylic acids and esters
- 专利标题(中): 中间体制备2,2-二甲基-3-芳基 - 环丙烷羧酸和酯
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申请号: US669182申请日: 1984-11-07
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公开(公告)号: US4681952A公开(公告)日: 1987-07-21
- 发明人: Reinhard Lantzsch , Dieter Arlt , Manfred Jautelat
- 申请人: Reinhard Lantzsch , Dieter Arlt , Manfred Jautelat
- 申请人地址: DEX Leverkusen
- 专利权人: Bayer Aktiengesellschaft
- 当前专利权人: Bayer Aktiengesellschaft
- 当前专利权人地址: DEX Leverkusen
- 主分类号: C07C69/753
- IPC分类号: C07C69/753 ; C07C45/00 ; C07C45/63 ; C07C45/65 ; C07C45/68 ; C07C49/223 ; C07C49/587 ; C07C49/657 ; C07C49/683 ; C07C49/697 ; C07C49/753 ; C07C51/00 ; C07C61/39 ; C07C61/40 ; C07C67/00 ; C07C201/00 ; C07C205/55 ; C07C227/00 ; C07C227/02 ; C07C229/46 ; C07C253/00 ; C07C255/56 ; C07C255/57 ; C07C313/00 ; C07C315/04 ; C07C317/24 ; C07C317/44 ; C07C319/20 ; C07C323/62 ; C07D307/46 ; C07D307/54 ; C07D307/56 ; C07D307/68 ; C07D307/70 ; C07D333/24 ; C07D333/28 ; C07D333/38 ; C07D333/42 ; C07F7/08 ; C07D307/02 ; C07D333/16
摘要:
A process for the preparation of 2,2-dimethyl-3-arylcyclopropanecarboxylic acid or ester of the formula ##STR1## in which Ar is naphthyl or the radical ##STR2## R.sup.1 is H or C.sub.1 -C.sub.4 -alkyl, Z is oxygen, sulphur, or 1,2-ethenediyl, andR.sup.2 represents hydrogen, halogen, cyano, nitro or trialkylsilyl or a radical, which is optionally substituted by halogen, from the series comprising alkyl, cycloalkyl, alkenyl, alkoxy, alkylenedioxy, alkylthio, alkylsulphinyl, alkylsulphonyl, dialkylamino, phenyl and phenoxy,comprising reacting a 1-aryl-1-halogeno-2,2-dimethyl-3-butanone of the formula ##STR3## in which X.sup.1 is chlorine or bromine, with a base in the presence of a diluent at a temperature between about -20.degree. and +150.degree. C., thereby to form a 2,2-dimethyl-3-arylcyclobutanone of the formula ##STR4## and reacting such 2,2-dimethyl-3-arylcyclobutanone with chlorine or bromine in the presence of an inert diluent at a temperature between about -30.degree. and +50.degree. C., reacting such 2,2-dimethyl-3-arylcyclobutanone with chlorine or bromine in the presence of an inert diluent at a temperature between about -30.degree. and +150.degree. C., thereby to form a 2,2-dimethyl-3-aryl-4-halogenocyclobutanone of the formula ##STR5## and reacting such 2,2-dimethyl-3-aryl-4-halogenocyclobutanone with an alkali metal alcoholate in the presence of an organic solvent or with an alkali metal or alkaline earth metal hydroxide or carbonate in the presence of water and an organic solvent, at a temperature between about -20.degree. and +100.degree. C. The various intermediates are new and the end product is a known intermediate for known insecticides.
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