The invention provides an apparatus which includes a syringe cartridge (10) having its open lower portion closed by a plunger piston (14). The upper portion is closed by a syringe cartridge closure (15) having a leur tip cap (50). Structure is optionally provided interiorly of the tip cap to retain a hollow needle (40), which is held in position by a leur tip (34), the latter being vented and provided with a seal for the needle. A displacement dome (38) is provided at the lower portion of the syringe cartridge closure (15) to displace a minor amount of fluid upon closure to seal the cartridge, and insure zero head space. The piston plunger (14) at the lower portion of the cartridge can be advanced, desirably by a second plunger (61), to empty the contents. Upon resealing, the leur tip cap (50) is applied over the leur tip (34) after a bead is formed on the tip. The tip cap (50) then penetrates the leur tip (34), or optionally the interior of the hollow needle (40) thus completely reclosing the cartridge and sealing the same for storage until intended for further use. Optionally, a metering screw plunger system (85,90,95,96) may be employed.