发明授权
US4645758A Urinary incontinence ameliorating dibenz- b,e- -oxepin and -thiepin
derivatives, compositions, and method of use therefor
失效
尿失禁改善二苯并b,e-氧化皮蛋白和硫蛋白衍生物,组合物及其使用方法
- 专利标题: Urinary incontinence ameliorating dibenz- b,e- -oxepin and -thiepin derivatives, compositions, and method of use therefor
- 专利标题(中): 尿失禁改善二苯并b,e-氧化皮蛋白和硫蛋白衍生物,组合物及其使用方法
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申请号: US820428申请日: 1986-01-17
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公开(公告)号: US4645758A公开(公告)日: 1987-02-24
- 发明人: Nils-Erik Willman , Bengt C. H. Sjogren , Lennart G. Nordh , Gustav L. Persson , Goran H. Sjoholm
- 申请人: Nils-Erik Willman , Bengt C. H. Sjogren , Lennart G. Nordh , Gustav L. Persson , Goran H. Sjoholm
- 专利权人: Willman Nils Erik,Sjoegren Bengt C H,Nordh Lennart G,Persson Gustav L,Sjoeholm Goeran H
- 当前专利权人: Willman Nils Erik,Sjoegren Bengt C H,Nordh Lennart G,Persson Gustav L,Sjoeholm Goeran H
- 优先权: SEX8500273 19850122
- 主分类号: C07D493/10
- IPC分类号: C07D493/10 ; A61K31/00 ; A61K31/335 ; A61K31/38 ; A61P13/02 ; A61P15/00 ; C07D313/12 ; C07D337/12 ; C07D405/06 ; C07D493/04 ; C07D493/14 ; C07D493/20 ; C07D493/22 ; C07D495/04 ; C07D495/10 ; C07D495/14 ; C07D495/20 ; C07D495/22 ; C07D498/10 ; C07D498/20 ; C07D498/22 ; A61K31/36
摘要:
The invention concerns:Novel dibenz/b,e/oxepin and dibenz/b,e/thiepin compounds having the general formula: ##STR1## wherein X is O or S,R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and are each selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulponyl, halogen, trifluoromethyl, trifluoromethylthio, lower dialkylsulphonamido, nitro, hydroxy, cyano, carbamyl, carboxy, lower alkoxycarbonyl, amino, N-lower alkylamino, N,N-diloweralkylamino, lower acylamido, lower alkanesulfonamido and lower acyl and, when on adjacent carbon atoms at the positions 2 and 3 and/or 8 and 9, two of the substituents R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 taken together may form a methylenedioxy group;R.sup.5 and R.sup.6 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aralkyl, lower hydroxyalkyl, lower aminoalkyl, lower alkylaminoalkyl, lower dialkylaminoalkyl, lower alkoxyalkyl and together with the nitrogen atom, R.sup.5 and R.sup.6 may form a 5- or 6- membered ring, such as pyrrolidine, piperidine, morpholine, piperazine, and N-lower alkyl or N-hydroxy lower alkyl substituted rings such as N-alkylpiperazine or N-hydroxyalkyl piperazine or the like,R.sup.7 is hydrogen or lower alkyl; optionally in the form of addition salts with pharmaceutically acceptable inorganic or organic acids and optionally in the form of essentially pure enantiomers.The invention also includes compositions containing the novel compounds, processes for their preparation and a method of treatment therewith.The compounds have pharmacological effects.
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