发明授权
- 专利标题： Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
- 专利标题（中）： 新型五肽，其制备方法，包含所述五肽的药物组合物及其用途
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申请号： US282045申请日： 1981-07-10
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公开(公告)号： US4405607A公开(公告)日： 1983-09-20
- 发明人: Francois Cardinaux , Rene Huguenin , Janos Pless
- 申请人： Francois Cardinaux , Rene Huguenin , Janos Pless
- 申请人地址： CHX Basel
- 专利权人： Sandoz Ltd.
- 当前专利权人： Sandoz Ltd.
- 当前专利权人地址： CHX Basel
- 优先权： CHX5483/80 19800717; CHX8752/80 19801126
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/70 ; A61K37/00 ; C07C103/52
摘要：
Pentapeptides of formula I, ##STR1## wherein Z.sup.1 =H, CH.sub.3 or amidino; R.sub.1 =H or alkyl and R.sub.2 =H or R.sub.1 +R.sub.2 =--CH.sub.2 --CH.sub.2 --; R.sub.3 =m- or p--OH or -alkoxy; B=residue of a (D)-.alpha.-amino acid; R.sub.4 =H or alkyl; Z.sup.2 =optionally substituted phenyl; and E=.beta.-amino alcohol residue (whereby when Z.sup.1 =H or CH.sub.3, R.sub.4 =C.sub.3-4 -alkyl) as well as their esters and the acid addition salts and complexes of such peptides and esters. Compounds according to the invention have valuable pharmacological, in particular LH-secretion inhibiting activity.
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