发明授权
US4308278A Anorexigenic 4-[(3,4-dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives
失效
厌氧性4 - [(3,4-二烷氧基苯基)烷基] -2-咪唑烷酮衍生物
- 专利标题: Anorexigenic 4-[(3,4-dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives
- 专利标题(中): 厌氧性4 - [(3,4-二烷氧基苯基)烷基] -2-咪唑烷酮衍生物
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申请号: US90450申请日: 1979-11-01
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公开(公告)号: US4308278A公开(公告)日: 1981-12-29
- 发明人: Geza Schneider , Ferenc Andrasi , Pal Berzsenyi , Arpad Lazar , Sandor Elek , Istvan Elekes , Istvan Polgari
- 申请人: Geza Schneider , Ferenc Andrasi , Pal Berzsenyi , Arpad Lazar , Sandor Elek , Istvan Elekes , Istvan Polgari
- 申请人地址: HUX Budapest
- 专利权人: Gyogyszerkutato Intezet
- 当前专利权人: Gyogyszerkutato Intezet
- 当前专利权人地址: HUX Budapest
- 优先权: HUXGO1429 19780111
- 主分类号: A61K31/415
- IPC分类号: A61K31/415 ; A61K31/4166 ; A61P1/00 ; A61P3/04 ; C07C45/71 ; C07D233/32 ; C07D233/34 ; C07D233/38 ; C07D233/78
摘要:
4-[(3,4-Dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives having the formula I ##STR1## wherein R.sup.1 stands for a cycloalkyl group containing from 3 to 6 carbon atoms or benzyl group;R.sup.2 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.3 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.4 stands for hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms or an alkoxycarbonyl group containing from 1 to 4 carbon atoms; andR.sup.5 stands for hydrogen atom or an alkoxycarbonyl group containing from 1 to 4 carbon atoms,are prepared by(a) reducing a hydantoin derivative having the general formula II, wherein R.sup.1 and R.sup.2 are as defined above, with lithium aluminum hydride in a neutral organic solvent, or(b) hydrogenating catalytically an 1,3-dihydro-2H-imidazol-2-one derivative having the general formula III, wherein R.sup.1 and R.sup.3 are as defined above, while the meaning of R.sup.4 is hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, or(c) reacting a carbamate derivative having the general formula IV, wherein R.sup.1 is as defined above, while R.sup.6 stands for an alkyl group containing from 1 to 4 carbon atoms, with an organic or inorganic base.The compounds having the formula I possess valuable therapeutical properties, mainly anorexigenic activity.
公开/授权文献
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