A method and device for cleaning a rotor in an open-end spinning machine. While the rotor is running at a speed less than the normal r.p.m. a first flow of cleaning air is directed to a collecting groove of the rotor and a second flow of cleaning air is simultaneously directed to the periphery of the spinning rotor at an angle different from the first flow of air. In one embodiment, at least one of the flows of air is directed in a pulsating manner. The flows or streams of air are fed through ducts provided in an extension of a cover which extends within the rotor or is supplied to the rotor by means of a movable housing.