发明授权
US4209616A Syn isomers of cephalosporins having .alpha.-hydroximino- or
.alpha.-acyloxyiminoacylamido groups at position-7
失效
在7位具有α-羟肟基 - 或α-酰氧基亚氨基酰氨基的头孢菌素的同分异构体
- 专利标题： Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7
- 专利标题（中）： 在7位具有α-羟肟基 - 或α-酰氧基亚氨基酰氨基的头孢菌素的同分异构体
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申请号： US951761申请日： 1978-10-16
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公开(公告)号： US4209616A公开(公告)日： 1980-06-24
- 发明人: Michael Gregson , Martin C. Cook , Gordon I. Gregory
- 申请人： Michael Gregson , Martin C. Cook , Gordon I. Gregory
- 申请人地址： GB2 Greenford
- 专利权人： Glaxo Laboratories Limited
- 当前专利权人： Glaxo Laboratories Limited
- 当前专利权人地址： GB2 Greenford
- 优先权： GBX3531/71 19710129; GBX45885/71 19711001
- 主分类号： C07C259/02
- IPC分类号： C07C259/02 ; C07D307/54 ; C07D333/24 ; C07D501/26 ; C07D501/20
摘要：
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.
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