发明授权
US3965117A Stereospecific total steroidal synthesis via substituted c/d-trans
indanones
失效
通过取代的c / d反式茚满酮进行立体特异性总体甾体合成
- 专利标题: Stereospecific total steroidal synthesis via substituted c/d-trans indanones
- 专利标题(中): 通过取代的c / d反式茚满酮进行立体特异性总体甾体合成
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申请号: US482541申请日: 1974-06-24
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公开(公告)号: US3965117A公开(公告)日: 1976-06-22
- 发明人: Zoltan George Hajos
- 申请人: Zoltan George Hajos
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 主分类号: C07C62/26
- IPC分类号: C07C62/26 ; C07C62/38 ; C07C103/19
摘要:
Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic compounds of the formula ##SPC1##Wherein m is an integer having a value of 1 or 2; R.sub.4 is hydrogen or lower alkyl; Z is lower alkylenedioxy, CH(OR.sub.2) and carbonyl; R.sub.8 when taken alone is hydrogen; R.sub.9 when taken alone is lower alkoxycarbonyl, aryloxy-carbonyl, lower cycloalkyloxycarbonyl, carbonyl-halide, hydrogen, carboxy, formyl and methylene-X, where X is a leaving group and when taken together are methylene; with the proviso that when Z is carbonyl R.sub.8 when taken alone is hydrogen; R.sub.8 when taken alone is carbonyl halide, hydrogen, carboxy, formyl and methylene-X where X is a leaving group and when taken together are methylene and R.sub.2 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenyl-lower alkyl, tetrahydropyranyl, lower alkanoyl, benzoyl, nitrobenzoyl, carboxy-lower alkanoyl, carboxybenzoyl, trifluoroacetyl and camphorsulfonyl.
公开/授权文献
- US5022924A Method for reducing the abrasion of calcined clay 公开/授权日:1991-06-11
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