发明授权
- 专利标题： Novel pregnanoic acid derivatives
- 专利标题（中）： 新型孕酸衍生物
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申请号： US45941274申请日： 1974-04-09
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公开(公告)号： US3906095A公开(公告)日： 1975-09-16
- 发明人: LAURENT HENRY , WIECHERT RUDOLF , PREZEWOWSKY KLAUS , HOFMEISTER HELMUT , GERHARDS ERICH , KOLB KARL HEINZ , MENGEL KLAUS
- 申请人： SCHERING AG
- 专利权人： Bayer Schering Pharma AG
- 当前专利权人： Bayer Schering Pharma AG
- 优先权： US45941274 1974-04-09; US28471072 1972-08-30
- 主分类号： A61K31/573
- IPC分类号： A61K31/573 ; A61K17/00
摘要：
Pregnanoic acid derivatives of the formula
WHEREIN X is hydrogen, halogen, or methyl; Y is hydrogen or halogen; Z is hydroxy or halogen having an atomic weight no greater than Y; R1 is hydrogen or methyl; R2 is hydrogen, alkali metal or saturated or unsaturated hydrocarbon of 1-18 carbon atoms which is unsubstituted or substituted by hydroxy, halo, alkoxy, carboxy, carbalkoxy, amino, alkylamino, dialkylamino, nitro or sulfate, wherein alkyl in each instance contains 1-4 carbon atoms; and -A-B- is -CH CH-; -CCl CH- or, when at least one of X, Y and R1 is other than hydrogen, -CH2-CH2; possess pronounced topical anti-inflammatory activity.
WHEREIN X is hydrogen, halogen, or methyl; Y is hydrogen or halogen; Z is hydroxy or halogen having an atomic weight no greater than Y; R1 is hydrogen or methyl; R2 is hydrogen, alkali metal or saturated or unsaturated hydrocarbon of 1-18 carbon atoms which is unsubstituted or substituted by hydroxy, halo, alkoxy, carboxy, carbalkoxy, amino, alkylamino, dialkylamino, nitro or sulfate, wherein alkyl in each instance contains 1-4 carbon atoms; and -A-B- is -CH CH-; -CCl CH- or, when at least one of X, Y and R1 is other than hydrogen, -CH2-CH2; possess pronounced topical anti-inflammatory activity.
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