发明授权
- 专利标题： Certain diazathiabicycloheptane derivatives
- 专利标题（中）： 某些衍生物衍生物衍生物
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申请号： US16787471申请日： 1971-07-30
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公开(公告)号： US3900487A公开(公告)日： 1975-08-19
- 发明人: UNDERWOOD WILLIAM GEORGE ELPHI , LONG ALAN GIBSON
- 申请人： GLAXO LAB LTD
- 专利权人： Glaxo Lab Ltd
- 当前专利权人： Glaxo Lab Ltd
- 优先权： GB3718770 1970-07-31
- 主分类号： A61K31/425
- IPC分类号： A61K31/425 ; C07D20060101 ; C07D495/04 ; C07D513/04 ; C07D99/10
摘要：
Novel semisynthetic thiazolidine derivatives of formula
WHERE R1 is the residue of an acyl group R1CO- containing 1-21 carbon atoms are provided by reduction of the corresponding Delta 3-thiazoline, the thiazolidine derivatives being of use in the production of cephalosporins, penicillins and related Beta lactam antibiotics. The preparation and use of such thiazolines and thiazolidines in N-protected forms are also described. The Delta 3-thiazoline starting materials may be obtained from penicillins without changing the configuration of the Beta lactam structure desired in the final product.
WHERE R1 is the residue of an acyl group R1CO- containing 1-21 carbon atoms are provided by reduction of the corresponding Delta 3-thiazoline, the thiazolidine derivatives being of use in the production of cephalosporins, penicillins and related Beta lactam antibiotics. The preparation and use of such thiazolines and thiazolidines in N-protected forms are also described. The Delta 3-thiazoline starting materials may be obtained from penicillins without changing the configuration of the Beta lactam structure desired in the final product.
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