发明授权
US3741969A Certain 3 - (beta-carbethoxyethyl)- and 3 - (beta-carboxyethyl) - 4 -phenyl-3,4-dihydro-and 1,2,3,4-tetrahydro-quinazolines
失效
某些3-（β-甲氧基乙基） - 和3-（β-羧基乙基）-4-苯基-3,4-二氢 - 和1,2,3,4-四氢喹啉酮
- 专利标题： Certain 3 - (beta-carbethoxyethyl)- and 3 - (beta-carboxyethyl) - 4 -phenyl-3,4-dihydro-and 1,2,3,4-tetrahydro-quinazolines
- 专利标题（中）： 某些3-（β-甲氧基乙基） - 和3-（β-羧基乙基）-4-苯基-3,4-二氢 - 和1,2,3,4-四氢喹啉酮
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申请号： US3741969D申请日： 1971-01-18
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公开(公告)号： US3741969A公开(公告)日： 1973-06-26
- 发明人: OTT H
- 申请人： SANDOZ AG
- 专利权人： Sandoz Ag
- 当前专利权人： Sandoz Ag
- 优先权： US10747771 1971-01-18; US60040366 1966-12-09
- 主分类号： C07D239/74
- IPC分类号： C07D239/74 ; C07D245/06 ; C07D51/48
摘要：
THE INVENTION DISCLOSES COMPOUNDS OF THE CLASS OF 6PHENYL-3,4-DIHYDRO(1,5)BENZODIAZOCIN-2-(IH)-ONES USEFUL AS TRANQUILIZERS. ALSO DISCLOSED IS PREPARATION OF SAID COMPOUNDS FEATURING INTERMEDIATES WHICH ARE 1,5-METHANO-1, 5-BENZODIAZOCIN-2-ONES WHICH ARE CONVERTED BY ACID TREATMENT TO THE CORRESPONDING 6-PHENYL-3,4,5,6-TETRAHYDRO(1, 5)BENZODIAZOCIN-2-(1H)-ONES WHICH IN TURN MAY BE OXIDIZED TO OBTAIN THE FIRST-MENTIONED CLASS OF COMPOUNDS. THE BRIDGE INTERMEDIATES ARE PREPARED BY DEHYDRATION OF A 3-(B-CARBOXYETHYL)-4-PHENYL-1,2,3,4-TETRAHYDROQUINAZOLINE WHICH IS PREPARED BY REDUCTION OF A 3-(B-CARBOXYETHYL)-4-PHENYL-3,4-DIHYDROQUINAZOLINE WHICH IS PREPARED BY HYDROLYSIS OF A CORRESPONDING ESTER.
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