A medical manipulator system includes a medical manipulator having an insertion portion to be intracorporeally inserted, a drive device to which the medical manipulator is detachably connected, and a controller which is communicatively connected to the drive device and to which a manipulation input for driving the medical manipulator is input. The controller has a groove engaged with a part of the medical manipulator. The medical manipulator has a connection portion and an extracorporeal flexible portion. The connection portion rotatably connects the insertion portion and the extracorporeal flexible portion around a rotation axis extending in a longitudinal direction of the medical manipulator. The connection portion has a fitting portion fitted with the groove of the controller.