A composition and method for improving mental function and physical performance with aging is disclosed. The composition comprises Rhus succedanea stem extract standardized for Fisetin, Piper longum root extract standardized for Piperlongumine, and Sophora japonica L. flower extract standardized for Quercetin. The composition may optionally include Sophora japonica L. flower extract standardized for Luteolin, Curcuma longa root standardized for curcuminoids, Olive Leaf extract standardized for olive polyphenols, milk thistle seed extract standardized for silymarin, soybean seed extract standardized for soy isoflavones, and Senactive® senolytic or combinations thereof. The composition is formulated for oral administration and may be taken intermittently for a couple to a few days at a time, followed by a week to several weeks without supplementation, with this dosing regimen repeated.