A collision cell is disclosed that comprises of a support and a target material. The parent ions entering the cell are accelerated and collide with the target material resulting in their fragmentation. The target material can be made from any suitable materials such as graphene, carbon, silicon, a combination of these materials, or alloys which have an atomic or molecular structure. The target material and the support are so selected to optimize the fragmentation process for a particular range of molecules and ions. The fragmented ions produced within the collision or fragmentation zone are focused and collected by a set of lenses positioned on the downstream side of the cell.