An aseptic junction device for a tube includes a tubular insert having a first end segment and a second end segment, an annular body mounted on the second end segment of the insert, and an annular sealing element. A maneuvering sleeve is rotatably mounted between a connection position and a disconnection position, and is coupled to the insert so that a rotation of the sleeve from the connection position to the disconnection position leads an axial movement of the body from a projecting position to a flush position. A coupling is arranged to allow decoupling of the junction device and another junction device, only when the sleeve is in the disconnection position.