Invention Publication
- Patent Title: BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF
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Application No.: US18601428Application Date: 2024-03-11
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Publication No.: US20240360139A1Publication Date: 2024-10-31
- Inventor: R. Bruce DIEBOLD , Wongil LEE , William DEVINE , So Young HWANG , Anu GUPTA , Vinay SAGAR , Nicholas NG , Sang-Ae SEUNG , Miyong YONG , Jaekyoo LEE , Jong Sung KOH
- Applicant: GENOSCO Inc.
- Applicant Address: US MA Billerica
- Assignee: GENOSCO Inc.
- Current Assignee: GENOSCO Inc.
- Current Assignee Address: US MA Billerica
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/4155 ; A61K31/416 ; A61K31/437 ; A61K31/519 ; C07D405/14 ; C07D471/04
Abstract:
The present invention relates to novel blood-brain barrier (BBB) penetrable substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.
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