Invention Publication
- Patent Title: Method of Enhancing Gene Therapy by Targeting cGAS-STING Pathway
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Application No.: US18685681Application Date: 2022-07-22
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Publication No.: US20240350667A1Publication Date: 2024-10-24
- Inventor: Xavier Anguel , Pedro Cejas , Ali Nahvi , Mustafa Yazicioglu, III , Rui Zhang
- Applicant: Spark Therapeutics, Inc.
- Applicant Address: US PA Philadelphia
- Assignee: Spark Therapeutics, Inc.
- Current Assignee: Spark Therapeutics, Inc.
- Current Assignee Address: US PA Philadelphia
- International Application: PCT/US2022/074084 2022.07.22
- Date entered country: 2024-02-22
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K9/127 ; A61K9/51 ; A61K31/404 ; A61K31/437 ; A61K45/06 ; C12N15/88
Abstract:
The present invention features method and composition that can be used to facilitate intracellular delivery of DNA to a subject. The provided methods and compositions employ a nanoparticle for intracellular DNA delivery and a cytosolic DNA-sensing inhibitor. The cytosolic DNA-sensing inhibitor is provided to decrease the subject's immune response that can be stimulated by the DNA.
Information query
