A smoking cessation system may include a nicotine delivery device to deliver a mixture in an aerosol form to a user, through pulmonary delivery. The mixture may include nicotine. The system may be prescription, over-the-counter, or non-prescription based. The smoking cessation system may also include a health hub to communicate with the nicotine delivery device and to control operation of the nicotine delivery device based on information. Such information may include, for example, information relating to the use of the nicotine delivery device by the user. One or more additional devices (e.g., a continuous monitoring device that detects nicotine content and use, including through metabolites such as cotinine or carbon monoxide) may communicate one or more items of the information to the health hub for the purpose of assisting the user to quit smoking.