Invention Publication
- Patent Title: METHODS AND COMPOSITIONS RELATED TO MODIFIED METHYLTRANSFERASES AND ENGINEERED BIOSENSORS
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Application No.: US18436635Application Date: 2024-02-08
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Publication No.: US20240336900A1Publication Date: 2024-10-10
- Inventor: Andrew Ellington , Simon d’Oelsnitz , Daniel Diaz
- Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12P17/18 ; G16B15/00 ; G16B40/20
Abstract:
This invention relates to non-naturally occurring methyltransferase, wherein said methyltransferase can methylate norbelladine to form 4-O'Methylnorbelladine. The invention is also drawn to a biosensor for detecting 4-O'Methylnorbelladine, wherein the biosensor comprises an engineered substrate-promiscuous regulator, wherein said substrate-promiscuous regulator has been engineered to interact more efficiently with 4-O'Methylnorbelladine than does a naturally occurring substrate promiscuous regulator; and further wherein the biosensor is engineered to provide an output signal, wherein said output signal is generated when the biosensor interacts with 4-O'Methylnorbelladine.
Information query
