Invention Publication
- Patent Title: METHODS OF USING CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN AND USES THEREOF
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Application No.: US18749513Application Date: 2024-06-20
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Publication No.: US20240335475A1Publication Date: 2024-10-10
- Inventor: Renier J. Brentjens , Eric L. Smith , Cheng Liu
- Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER , EUREKA THERAPEUTICS, INC.
- Applicant Address: US NY New York
- Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee Address: US NY New York; US CA Emeryville
- The original application number of the division: US16844610 2020.04.09
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61P35/00 ; C07K14/705 ; C07K14/725 ; C07K16/28
Abstract:
The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target B cell maturation antigen (BCMA), and immunoresponsive cells comprising such CARs. The presently disclosed BCMA-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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