- 专利标题: HER2 SINGLE DOMAIN ANTIBODIES VARIANTS AND CARS THEREOF
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申请号: US18269615申请日: 2022-01-14
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公开(公告)号: US20240317890A1公开(公告)日: 2024-09-26
- 发明人: Franck PEREZ , Sandrine MOUTEL , Zélia GOUVEIA
- 申请人: INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , HONING BIOSCIENCES
- 申请人地址: FR Paris
- 专利权人: INSTITUT CURIE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -,HONING BIOSCIENCES
- 当前专利权人: INSTITUT CURIE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -,HONING BIOSCIENCES
- 当前专利权人地址: FR Paris
- 优先权: EP 305040.4 2021.01.14
- 国际申请: PCT/EP2022/050767 2022.01.14
- 进入国家日期: 2023-06-26
- 主分类号: C07K16/32
- IPC分类号: C07K16/32 ; A61K39/00 ; C07K14/705 ; C07K14/725 ; G01N33/574
摘要:
The present invention relates to humanized HER2 single domain antibodies and variants thereof and their use in therapy and for cancer diagnosis. The invention most particularly proposes chimeric antigen receptors including said humanized HER2 sdAb in their antigen binding domain and their use in cancer cell therapy.
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