A medical device for assessing clinical patient deterioration in an in-patient hospital environment is provided. The medical device includes a processor and sensors that couple externally to a skin of the patient to acquire electrocardiogram (ECG) and other physiologic signals. The processor is configured to receive a medical history of the patient; generate physiologic data, including ECG data, over a period of time based on one or more physiologic signals; and execute a risk assessment process associated with a clinical condition of the patient. The risk assessment process analyzes the physiologic data and the medical history of the patient to generate a risk estimate of deterioration of the patient's clinical condition.