Invention Publication
- Patent Title: MODIFIED DOUBLE-STRANDED DONOR TEMPLATES
-
Application No.: US18679324Application Date: 2024-05-30
-
Publication No.: US20240309350A1Publication Date: 2024-09-19
- Inventor: Jessica Woodley , Bernice Thommandru , Joseph Dobosy , Mark Behlke , Adam Clore , Garrett Rettig , Beimeng Sun
- Applicant: INTEGRATED DNA TECHNOLOGIES, INC.
- Applicant Address: US IA Coralville
- Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
- Current Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
- Current Assignee Address: US IA Coralville
- The original application number of the division: US17079097 2020.10.23
- Main IPC: C12N9/22
- IPC: C12N9/22 ; C12N15/113 ; C12N15/66
Abstract:
Described herein are compositions and methods for improving homology directed repair (HDR) efficiency and reducing homology-independent integration following introduction of double strand breaks with engineered nucleases. Additionally, modifications to double stranded DNA donors to improve the donor potency and efficiency of homology directed repair following introduction of double stranded breaks with programmable nucleases.
Information query
