Invention Publication
- Patent Title: PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION
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Application No.: US18660578Application Date: 2024-05-10
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Publication No.: US20240308964A1Publication Date: 2024-09-19
- Inventor: Didier SCHERRER , Jamal TAZI , Florence MAHUTEAU-BETZER , Romain NAJMAN , Julien SANTO , Cécile APOLIT
- Applicant: ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE MONTPELLIER , INSTITUT CURIE
- Applicant Address: FR Paris
- Assignee: ABIVAX,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE DE MONTPELLIER,INSTITUT CURIE
- Current Assignee: ABIVAX,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE DE MONTPELLIER,INSTITUT CURIE
- Current Assignee Address: FR Paris; FR Paris; FR Montpellier; FR Paris
- Priority: EP 305910.4 2018.07.09
- The original application number of the division: US17259364 2021.01.11
- Main IPC: C07D215/38
- IPC: C07D215/38 ; A61P31/14 ; C07D401/12 ; C07D405/12
Abstract:
A compound of formula (I) or any of its pharmaceutically acceptable salt for use in the treatment and/or prevention of a RNA virus infection, and a RNA virus infection from group IV or V of the Baltimore classification
wherein R3 represents a chlorine atom or a hydrogen atom, R represents a (C1-C4)alkyl group, a (C3-C6)cycloalkyl group, a halogen atom, a (C1-C5)alkoxy group, a —SO2—NRaRb group, a —SO3H group, a —OH group, a —O—SO2—ORc group or a —O—P(═O)—(ORc)(ORd) group, R1 represents (i) a CF3 group, (ii) a (C1-C10)alkyl group, (iii) a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group or (iv) a phenyl group or a naphthyl group, and R2 represents a hydrogen atom, a (C1-C10)alkyl group, a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group and further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.
wherein R3 represents a chlorine atom or a hydrogen atom, R represents a (C1-C4)alkyl group, a (C3-C6)cycloalkyl group, a halogen atom, a (C1-C5)alkoxy group, a —SO2—NRaRb group, a —SO3H group, a —OH group, a —O—SO2—ORc group or a —O—P(═O)—(ORc)(ORd) group, R1 represents (i) a CF3 group, (ii) a (C1-C10)alkyl group, (iii) a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group or (iv) a phenyl group or a naphthyl group, and R2 represents a hydrogen atom, a (C1-C10)alkyl group, a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group and further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.
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