A method for calibrated multi-mineral, multi-fluid interpretation is provided herein. The method includes generating a multi-mineral, multi-fluid interpretation model for a number of log types using core and/or specialized log data acquired from subsurface region(s) that relate to components within the subsurface region(s). Generating the model includes: (1) for each log type, calibrating component end-members for the log type via an inversion of the core and/or specialized log data relating to the components across all depths of interest; and (2) incorporating the resulting calibrated end-members for the log types into the model. The method also includes generating component volume fraction profiles using log data acquired from analogous subsurface region(s) using the model, wherein the log data relate to any of the log types used to generate the model. Each component volume fraction profile includes a range of component volume fractions that accounts for a degree of uncertainty within the model.