A tool-integrated medical waste sterilization processing barrel includes a treatment barrel, a discharge port set at a bottom edge of the treatment barrel, and an integrated cutting tool is provided at the bottom of the treatment barrel; the integrated cutting tool includes a mounting block in a shape of truncated square pyramid, the mounting block has a cutter on each bevel, the cutter is in a plane parallel to the corresponding bevel of the mounting block, the mounting block has a power chamber with a downward opening, the power chamber has a power member, the input end of the cutter extends into the power chamber and is connected to the output end of the power member, and a rotating member is connected between the mounting block and the treatment barrel.