An audio control method, a control device, a driving circuit and a readable storage medium are provided. The audio control method according to some embodiments of the present disclosure is applicable to the display screen configured with M speakers, and the method includes: obtaining a sound image coordinate of a sound object relative to the display screen; determining N speakers from the M speakers as loudspeakers according to the sound image coordinate and position coordinates of the M speakers relative to the display screen; determining output gains of the N loudspeakers according to distances between the N loudspeakers and a viewer of the display screen and sound attenuation coefficients; and calculating output audio data of the sound object in the display screen according to audio data of the sound object and the output gains of the N loudspeakers, and controlling the M speakers to play the output audio data.