According to embodiments of the present disclosure, an Information Handling System (IHS), systems and methods for dynamic policy assignment of secure communication using Security Protocol and Data Model (SPDM) are disclosed. An Information Handling System (IHS) includes a first SPDM-enabled device conforming to a SPDM specification, receives a request to transmit data to a second SPDM-enabled device, obtain one or more policies associated with a corresponding one or more transmission criteria of the first SPDM-enabled device relative to the second SPDM-enabled device, and determine whether the data is to be encrypted based upon whether a transmission of the data meets the transmission criteria. Based upon the determination, encrypt the data prior to transmitting the data to the second SPDM-enabled device.