Disclosed herein are biotherapeutics comprising probiotics or a consortium of probiotics. Disclosed herein are biotherapeutics comprising factors secreted from probiotics or factors secreted from a consortium of probiotics. Disclosed herein are also pharmaceutical formulations comprising a disclosed biotherapeutic. Also disclosed are methods of promoting respiratory health, reducing the risk of developing and infection, treating and/or preventing a bacterial colonization and/or infection, and modulating microbial diversity and/or composition.