This application relates to the field of oil and gas devices, systems, and methods, and particularly relates to a packing leakage detection system and method. The packing leakage detection system includes a plunger pump, a pressure sensor and a control system, where the pressure sensor is configured to detect a pressure value inside a hydraulic end of the plunger pump, and send the detected pressure value to the control system; and the control system is configured to acquire the pressure value sent by the pressure sensor, and send prompt information according to the pressure value, where the prompt information includes at least one of alarm information and information for prompting shutdown and overhaul. This application is used for solving the problem that a leakage anomaly caused by a packing failure is not discovered in time.