Invention Publication
- Patent Title: CYSTINE KNOT SCAFFOLD PLATFORM
-
Application No.: US18497741Application Date: 2023-10-30
-
Publication No.: US20240247034A1Publication Date: 2024-07-25
- Inventor: Rami HANNOUSH , Harini KALUARACHCHI , Aaron NILE , Cameron NOLAND , Yingnan ZHANG , Lijuan ZHOU , Xinxin GAO
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- The original application number of the division: US15267087 2016.09.15
- Main IPC: C07K14/415
- IPC: C07K14/415 ; A61K9/00 ; A61K9/50 ; A61K38/00 ; A61K38/16 ; A61K47/34 ; C07K14/00 ; C07K14/47 ; C07K14/81
Abstract:
Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
Information query
