- 专利标题： CYCLIC BENZIMIDAZOLE DERIVATIVES AS CGAS INHIBITORS
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申请号： US18386979申请日： 2023-11-03
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公开(公告)号： US20240208997A1公开(公告)日： 2024-06-27
- 发明人: Annekatrin Charlotte HEIMANN , Alexander DREYER , Christian GNAMM , Cédrickx GODBOUT , Marc Alexander GRUNDL , Sandra Ruth HANDSCHUH , Christoph HOENKE , Joerg Thomas KLEY , Christian Andreas KUTTRUFF , Jun LI , Dirk REINERT , Raphael STUBER
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP 212494.3 2022.12.09
- 主分类号： C07D498/22
- IPC分类号： C07D498/22 ; A61K45/06 ; C07D491/048
摘要：
The invention relates to compounds of formula I
wherein R1, R2, R3, A, D, E, G, J, K and L are defined as in claim 1, and prodrugs, deuterated analogues and pharmaceutical acceptable salts thereof, for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
wherein R1, R2, R3, A, D, E, G, J, K and L are defined as in claim 1, and prodrugs, deuterated analogues and pharmaceutical acceptable salts thereof, for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
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