- 专利标题： APPLICATIONS OF BIASED LIGANDS OF THE SEROTONIN 5-HT7 RECEPTOR FOR THE TREATMENT OF PAIN, MULTIPLE SCLEROSIS AND THE CONTROL OF THERMOREGULATION
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申请号： US18551361申请日： 2022-03-18
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公开(公告)号： US20240199555A1公开(公告)日： 2024-06-20
- 发明人: Séverine MORISSET-LOPEZ , Franck SUZENET , Gérald GUILLAUMET , Emmanuel DEAU , Elodie ROBIN , Chayma EL KHAMLICHI , Flora REVERCHON-ASSADI , Nadège HERVOUET-COSTE , Fahima MADOURI , Marie-Aude HIEBEL , Julie LE-BESCONT
- 申请人： Centre National de la Recherche Scientifique , Université d'Orléans
- 申请人地址： FR PARIS
- 专利权人： Centre National de la Recherche Scientifique,Université d'Orléans
- 当前专利权人： Centre National de la Recherche Scientifique,Université d'Orléans
- 当前专利权人地址： FR PARIS
- 优先权： EP 315045.1 2021.03.19
- 国际申请： PCT/EP2022/057227 2022.03.18
- 进入国家日期： 2023-09-19
- 主分类号： C07D235/26
- IPC分类号： C07D235/26 ; A61K31/496 ; A61P29/00 ; C07D233/36 ; C07D401/12 ; C07D403/12 ; C07D487/10
摘要：
The present invention relates to a compound having the following formula (1)
wherein:
R and R′ are, independently from each other, H or (C1-C6)alkyl groups, or form together with the carbon atoms carrying them a (C6-C10)aryl group;
R2 is selected from the group consisting of: H, (C1-C6)alkyl group, halo(C1-C6)alkyl group, aryl, and heteroaryl;
A1 is a linker;
R″ is either a group (A-1) or a group (A-2)
for use in the treatment of a brain disorder involving modified 5-HT7R-mediated signaling, especially for use in the treatment of pain or inflammation or in the treatment of multiple sclerosis, or for use to induce hypothermia.
wherein:
R and R′ are, independently from each other, H or (C1-C6)alkyl groups, or form together with the carbon atoms carrying them a (C6-C10)aryl group;
R2 is selected from the group consisting of: H, (C1-C6)alkyl group, halo(C1-C6)alkyl group, aryl, and heteroaryl;
A1 is a linker;
R″ is either a group (A-1) or a group (A-2)
for use in the treatment of a brain disorder involving modified 5-HT7R-mediated signaling, especially for use in the treatment of pain or inflammation or in the treatment of multiple sclerosis, or for use to induce hypothermia.
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