- 专利标题： CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS
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申请号： US18237351申请日： 2023-08-23
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公开(公告)号： US20240156969A1公开(公告)日： 2024-05-16
- 发明人: Patrick J. BURKE , Joel COURTER
- 申请人： Seagen Inc.
- 申请人地址： US WA Bothell
- 专利权人： Seagen Inc.
- 当前专利权人： Seagen Inc.
- 当前专利权人地址： US WA Bothell
- 分案原申请号： US17533002 2021.11.22
- 主分类号： A61K47/55
- IPC分类号： A61K47/55 ; A61K9/00 ; A61K9/08 ; A61K31/454 ; A61K38/05 ; A61K38/06 ; A61K47/64 ; A61K47/65 ; A61K47/68 ; A61P35/02 ; C07K5/02
摘要：
Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
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