Invention Publication
- Patent Title: NATURAL KILLER CELL ANTIBODIES WITH INCREASED ADCC ACTIVITY
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Application No.: US18502668Application Date: 2023-11-06
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Publication No.: US20240150471A1Publication Date: 2024-05-09
- Inventor: Matthew S. Faber
- Applicant: Xencor, Inc.
- Applicant Address: US CA Pasadena
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Pasadena
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; C07K16/32
Abstract:
Described herein are antibodies, including multispecific antibodies, that bind to NK cells, optionally a tumor target antigen (TTA) and have increased binding to the CD16A receptor. The antibodies can include an NK cell antigen binding domain (ABD) that binds to the extracellular domain of an NK cell antigen such as NKG2D, NKp30, and NKp46.
Information query
