Invention Publication
- Patent Title: MATRIPTASE AND U-PLASMINOGEN ACTIVATOR SUBSTRATES AND OTHER CLEAVABLE MOIETIES AND METHODS OF USE THEREOF
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Application No.: US18534263Application Date: 2023-12-08
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Publication No.: US20240150402A1Publication Date: 2024-05-09
- Inventor: Stephen James MOORE , Margaret Thy Luu NGUYEN , Daniel Robert HOSTETTER , Olga VASILJEVA
- Applicant: CytomX Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: CytomX Therapeutics, Inc.
- Current Assignee: CytomX Therapeutics, Inc.
- Current Assignee Address: US CA South San Francisco
- The original application number of the division: US17240278 2021.04.26
- Main IPC: C07K7/06
- IPC: C07K7/06 ; A61K47/65 ; A61K47/68 ; A61K49/00 ; C07K7/08 ; C07K16/00 ; C07K16/28
Abstract:
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.
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