Conduit bore plugging for rapid selective plugging of a fluid path within a conduit has a driver handle having a motive chamber with a driving chamber, the motive chamber attached to the driver handle, wherein the motive chamber defines a passage. A shaft-like plugging device has a bar connected to a rod, wherein the bar is driven in a first direction by the driver handle via the driving chamber, and guided and supported by the motive via the passage. A fluid path in a conduit is selectively plugged with an expandable seal via expanding the expandable seal within the bore of the conduit by sliding a sleeve over a rod of the bar into a flange contiguous with an end of the expandable seal, and by engaging the sleeve at one end by interference with an abutment surface as the bar is driven via the driving chamber.