Invention Publication
- Patent Title: B-CELL MATURATION ANTIGEN (BCMA) ANTI-IDIOTYPIC ANTIBODIES
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Application No.: US18468854Application Date: 2023-09-18
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Publication No.: US20240101710A1Publication Date: 2024-03-28
- Inventor: Zea Melton , Tao Sai , Thomas John Van Blarcom
- Applicant: ALLOGENE THERAPEUTICS, INC. , PFIZER INC.
- Applicant Address: US CA South San Francisco
- Assignee: ALLOGENE THERAPEUTICS, INC.,PFIZER INC.
- Current Assignee: ALLOGENE THERAPEUTICS, INC.,PFIZER INC.
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07K16/42
- IPC: C07K16/42 ; A61K49/00 ; C07K1/22 ; C07K16/28 ; C12N5/0783 ; G01N33/569

Abstract:
Provided herein are anti-idiotype antibodies that specifically recognize anti-BCMA antibody moieties, in particular, anti-BCMA antibody moieties present in recombinant receptors, including chimeric antigen receptors (CARs). The disclosure further relates to uses of anti-idiotype antibodies for specifically identifying and/or selecting cells expressing such recombinant receptors, such as anti-BCMA CAR T cells. The disclosure further relates to uses of anti-idiotype antibodies for specifically activating such cells.
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